Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose? Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}},{"id":188642,"pharmainfo":{"html":"
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose? Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}},{"id":188643,"pharmainfo":{"html":"
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose? Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}},{"id":188644,"pharmainfo":{"html":"
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose? Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}},{"id":188645,"pharmainfo":{"html":"
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose? Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}},{"id":188646,"pharmainfo":{"html":"
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose? Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}},{"id":188647,"pharmainfo":{"html":"
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose? Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}},{"id":188648,"pharmainfo":{"html":"
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose? Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}},{"id":188649,"pharmainfo":{"html":"
\r\n\r\nWho is it for?
\r\nSimparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater.
\r\n
\r\nWhat are the benefits?
\r\n
\r\nHow does Simparica Trio work?
\r\nSimparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate.
\r\nSarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
\r\nMoxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
\r\nPyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
\r\n
\r\nIs there a generic equivalent available?
\r\nNo.\r\n
\r\nHow is it given?
\r\nSimparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused.
\r\nHeartworm Prevention:
\r\nSimparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure.
\r\nFlea Treatment and Prevention:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active.
\r\nTo minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
\r\nTick Treatment and Control:
\r\nTreatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active.
\r\nIntestinal Nematode Treatment and Control:
\r\nFor the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.
\r\n
\r\nWhat form(s) does it come in?
\r\nSimparica Trio comes in a liver-flavored chewable tablet.\r\n
\t\t\t\t\t\t\t\t\t\t\t\t\t\r\nBrand Name
\r\nSimparica Trio®\r\n
\r\nPronunciation
\r\nSim-PAIR-uh-ka Tree-O\r\n
\r\nCommon Drug Name
\r\nSarolaner, Moxidectin and Pyrantel Pamoate \r\n
\r\nWhat should I discuss with my veterinarian while considering Simparica Trio?
\r\nTalk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
\r\nSimparica Trio should be used with caution in dogs with a history of seizures. The safety of Simparica Trio has not been evaluated in pregnant, lactating or breeding dogs. Tell your veterinarian if your pet has epilepsy, could be pregnant, is lactating or is used for breeding.\r\n
\r\nAs with any medication, notify your veterinarian of any other medications or supplements your pet is taking, and if your pet has had any reactions to previous medications or supplements.\r\n
\r\nWhat should I do if I miss a dose?
\r\nIf a dose is missed, give Simparica Trio immediately and resume monthly dosing.\r\n
\r\nWarnings
\r\nNot for use in humans. Keep this and all drugs out of the reach of children. For use in dogs only. DO NOT use Simparica Trio in cats. Keep Simparica Trio in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.\r\n
\r\nPrecautions
\r\nSarolaner, one of the active ingredients in Simparica Trio, is a member of the isozaxoline class. This class has been associated neurologic adverse reactions including tremors, ataxia and seizures. Seizures have been reported in dogs taking isozaxoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.
\r\nPrior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. Immitis.
\r\n
\r\nWhat side effects may be seen when taking Simparica Trio?
\r\n\r\nMay see vomiting, , diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects.\r\n
\r\nIf your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.\r\n
\r\nHow is it stored?
\r\nStore at or below 86 degrees Farenheit. Keep out of reach of children and pets.\r\n
\r\nWhat should I do if I know of or suspect there has been an overdose?
\r\nIf you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately."}}]}